Intestinal immunity

October 30th, 2009  |  Published in Stumpblog  |  2 Comments

Breakthrough research describes a mechanism that links diet, gut bacteria and the immune system: GPR43, a molecule expressed by immune cells and previously shown to bind short chain fatty acids, functions as an anti-inflammatory receptor.

“The notion that diet might have profound effects on immune responses or inflammatory diseases has never been taken that seriously,” said Professor Mackay, the lead researcher. “We believe that changes in diet, associated with western lifestyles, contribute to the increasing incidences of asthma, Type 1 diabetes and other autoimmune diseases. Now we have a new molecular mechanism that might explain how diet is affecting our immune systems.”

Seriously guys? It never dawned on you that what you eat might make you sick or better?

Full story in Science Daily — bottom line (ha ha): eat more fibre, fruit and veg, yaddayadda the usual.


  1. Ammi says:

    November 2nd, 2009at 9:15 am(#)

    That’s an amazing spot! Thanks for sharing.

    I’m sure I’ve been reading for ages about diet and diet-caused intestine problems impacting the immune system, though suspeciously only on fitness and technical diet websites. I can’t believe he’s said that it hasn’t been taken seriously up to now. Surely he’s heard of leaky gut syndrome and the impact that has on the immune system (and the fact that a western diet is meant to make the condition worse)?

    As you say, it all seems a bit elementary that what you take into your body through food might impact on your immune system. Especially if there are small perforations in your gut lining from leaky gut syndrome (as an example).

  2. Debbie says:

    November 12th, 2009at 11:00 am(#)

    I couldn’t agree more. I have learn’t this the hard way. I have been diagnosed with having mild Endometriosis and suspected MS. My sister has very severe Endometriosis. After years of stomach problems and many other awful symptoms, my doctor mentioned in passing that he though I may have Candida Albicans (over growth of yeast in the gut). After months of research into diet (now feeling much better following a zero yeast and sugar diet), I strongly suspect that although Candida is argued to be a common secondary condition to auto immune diseases such as MS, Lupus, Endometriosis … I believe that it is the primary condition which may actually be the route of many auto immune conditions out there today. If I said this infront of a specialist I am sure I would be laughed at though … sad but true. I definately think there needs to be more research into this idea. I read a very convincing article about it the other day (I have this article if anyone is interested).

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